Lipid biomarkers provide evolutionary signposts for the oldest known cases of tuberculosis.
Identifieur interne : 000138 ( Main/Exploration ); précédent : 000137; suivant : 000139Lipid biomarkers provide evolutionary signposts for the oldest known cases of tuberculosis.
Auteurs : Oona Y-C Lee [Royaume-Uni] ; Houdini H T. Wu [Royaume-Uni] ; Gurdyal S. Besra [Royaume-Uni] ; Bruce M. Rothschild (médecin) [États-Unis] ; Mark Spigelman [Israël] ; Israel Hershkovitz [Israël] ; Gila Kahila Bar-Gal [Israël] ; Helen D. Donoghue [Royaume-Uni] ; David E. Minnikin [Royaume-Uni]Source :
- Tuberculosis (Edinburgh, Scotland) [ 1873-281X ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Biomarkers, Lipids, Mycolic Acids.
- chemical , genetics : Lipids.
- genetics : Tuberculosis, Osteoarticular.
- history : Tuberculosis, Osteoarticular.
- methods : Paleopathology.
- Animals, Biological Evolution, Cattle, Child, Preschool, Female, History, Ancient, Humans.
Abstract
Studies on the evolution of tuberculosis, and the influence of this disease on human and animal development and interaction, require the accumulation of indisputable biomarker evidence. Ideally, the determination of full genomes would provide all the necessary information, but for very old specimens DNA preservation may be compromised and only limited DNA amplification may be a possibility. Mycobacterium tuberculosis is characterised by the presence of unusual cell envelope lipids, with specific biomarker potential. Lipid biomarker recognition has been decisive in pinpointing the oldest known cases of human and animal tuberculosis; the former are a woman and child from a pre-pottery settlement at Atlit-Yam, Israel (∼9,000 ka) and the latter is an extinct Bison antiquus from Natural Trap Cave, Wyoming (∼17,000 ka). Including some new data, it is demonstrated how analysis of a combination of mycolic, mycocerosic and mycolipenic acid and phthiocerol biomarkers provide incontrovertible evidence for tuberculosis in these landmark specimens.
DOI: 10.1016/j.tube.2015.02.013
PubMed: 25797611
Affiliations:
- Israël, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Kansas, Midlands de l'Ouest
- Birmingham, Lawrence (Kansas), Londres
- University College de Londres, Université de Birmingham, Université du Kansas
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Le document en format XML
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Electronic address: spigelman@btinternet.com.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Kuvin Center for the Study of Infectious and Tropical Diseases and Ancient DNA, Hadassah Medical School, Hebrew University, Jerusalem</wicri:regionArea><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Hershkovitz, Israel" sort="Hershkovitz, Israel" uniqKey="Hershkovitz I" first="Israel" last="Hershkovitz">Israel Hershkovitz</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. 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Donoghue</name><affiliation wicri:level="4"><nlm:affiliation>Centres for Clinical Microbiology and the History of Medicine, University College London, UK. Electronic address: h.donoghue@ucl.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Centres for Clinical Microbiology and the History of Medicine, University College London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Minnikin, David E" sort="Minnikin, David E" uniqKey="Minnikin D" first="David E" last="Minnikin">David E. Minnikin</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK. Electronic address: d.e.minnikin@bham.ac.uk.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName><orgName type="university">Université de Birmingham</orgName></affiliation></author></analytic><series><title level="j">Tuberculosis (Edinburgh, Scotland)</title><idno type="eISSN">1873-281X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biological Evolution</term><term>Biomarkers (analysis)</term><term>Cattle</term><term>Child, Preschool</term><term>Female</term><term>History, Ancient</term><term>Humans</term><term>Lipids (analysis)</term><term>Lipids (genetics)</term><term>Mycolic Acids (analysis)</term><term>Paleopathology (methods)</term><term>Tuberculosis, Osteoarticular (genetics)</term><term>Tuberculosis, Osteoarticular (history)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Biomarkers</term><term>Lipids</term><term>Mycolic Acids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Lipids</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Tuberculosis, Osteoarticular</term></keywords><keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Tuberculosis, Osteoarticular</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Paleopathology</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biological Evolution</term><term>Cattle</term><term>Child, Preschool</term><term>Female</term><term>History, Ancient</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Studies on the evolution of tuberculosis, and the influence of this disease on human and animal development and interaction, require the accumulation of indisputable biomarker evidence. Ideally, the determination of full genomes would provide all the necessary information, but for very old specimens DNA preservation may be compromised and only limited DNA amplification may be a possibility. Mycobacterium tuberculosis is characterised by the presence of unusual cell envelope lipids, with specific biomarker potential. Lipid biomarker recognition has been decisive in pinpointing the oldest known cases of human and animal tuberculosis; the former are a woman and child from a pre-pottery settlement at Atlit-Yam, Israel (∼9,000 ka) and the latter is an extinct Bison antiquus from Natural Trap Cave, Wyoming (∼17,000 ka). Including some new data, it is demonstrated how analysis of a combination of mycolic, mycocerosic and mycolipenic acid and phthiocerol biomarkers provide incontrovertible evidence for tuberculosis in these landmark specimens.</div></front></TEI><affiliations><list><country><li>Israël</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Kansas</li><li>Midlands de l'Ouest</li></region><settlement><li>Birmingham</li><li>Lawrence (Kansas)</li><li>Londres</li></settlement><orgName><li>University College de Londres</li><li>Université de Birmingham</li><li>Université du Kansas</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Lee, Oona Y C" sort="Lee, Oona Y C" uniqKey="Lee O" first="Oona Y-C" last="Lee">Oona Y-C Lee</name></region><name sortKey="Besra, Gurdyal S" sort="Besra, Gurdyal S" uniqKey="Besra G" first="Gurdyal S" last="Besra">Gurdyal S. Besra</name><name sortKey="Donoghue, Helen D" sort="Donoghue, Helen D" uniqKey="Donoghue H" first="Helen D" last="Donoghue">Helen D. Donoghue</name><name sortKey="Minnikin, David E" sort="Minnikin, David E" uniqKey="Minnikin D" first="David E" last="Minnikin">David E. Minnikin</name><name sortKey="Wu, Houdini H T" sort="Wu, Houdini H T" uniqKey="Wu H" first="Houdini H T" last="Wu">Houdini H T. Wu</name></country><country name="États-Unis"><region name="Kansas"><name sortKey="Rothschild, Bruce M" sort="Rothschild, Bruce M" uniqKey="Rothschild B" first="Bruce M" last="Rothschild">Bruce M. Rothschild (médecin)</name></region></country><country name="Israël"><noRegion><name sortKey="Spigelman, Mark" sort="Spigelman, Mark" uniqKey="Spigelman M" first="Mark" last="Spigelman">Mark Spigelman</name></noRegion><name sortKey="Bar Gal, Gila Kahila" sort="Bar Gal, Gila Kahila" uniqKey="Bar Gal G" first="Gila Kahila" last="Bar-Gal">Gila Kahila Bar-Gal</name><name sortKey="Hershkovitz, Israel" sort="Hershkovitz, Israel" uniqKey="Hershkovitz I" first="Israel" last="Hershkovitz">Israel Hershkovitz</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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